Publications

Featured Publications

Reticker-Flynn, N.E.**, Zhang, W., Belk, J.A., Basto, P.A., Escalante, N.K., Pilarowski, G.O.W., Bejnood, A., Martins, M.M., Kenkel, J.A., Linde, I.L., Bagchi, S., Yuan, R., Chang, S., Spitzer, M.H., Carmi, Y., Cheng, J., Tolentino, L.L., Choi, O., Wu, N., Kong, C., Gentles, A.J., Sunwoo, J.B., Satpathy, A.T., Plevritis, S.K., Engleman, E.G.**, “Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.” Cell, May 2022. PMID: 35525247, DOI: 10.1016/j.cell.2022.04.019
** Co-corresponding authors
Highlighted in Nature Reviews Cancer, Nature Reviews Immunology, Cancer Discovery, Science Signaling, Trends in Cancer, NCI Cancer Currents

Spitzer, M.H.*, Carmi, Y.*, Reticker-Flynn, N.E.*, Kwek, S.S., Madhireddy, D., Martins, M.M., Gherardini, P.F., Prestwood, T.R., Chabon, J., Bendall, S.C., Fong, L., Nolan, G.P.**, Engleman, E.G.** “Systemic immunity is required for effective cancer immunotherapy.” Cell, January 2017. PMID: 28111070
* Co-lead authors; ** Co-last authors

Reticker-Flynn, N.E. and Bhatia, S.N. "Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche." Cancer Discovery. February 2015. PMCID: PMC4367955.
Highlighted in Nature Reviews Cancer, Cancer Discovery, and Nature

Reticker-Flynn, N.E., Braga Malta, D.F., Winslow, M.M., Lamar, J.M., Xu, M.J., Underhill, G.H., Hynes, R.O., Jacks, T.E., Bhatia, S.N. “A combinatorial extracellular matrix platform identifies cell-ECM interactions that correlate with metastasis.” Nature Communications. 3: October 9, 2012. PMCID: PMC3794716.

All Publications

McGinnis, C.S., Miao, Z., Superville, D., Yao, W., Goga, A., Reticker-Flynn, N.E., Winkler, J.**, Satpathy, A.T.** “The temporal progression of lung immune remodeling during breast cancer metastasis.” Cancer Cell, May 2024. PMID: 38821060, DOI:https://doi.org/10.1016/j.ccell.2024.05.004
** Co-corresponding authors

Basto, P.A. and Reticker-Flynn, N.E. “Interrogating the roles of lymph node metastasis in systemic immune surveillance.” Clinical & Experimental Metastasis, February 2024. DOI: https://doi.org/10.1007/s10585-023-10261-3

Reticker-Flynn, N.E.** and Engleman, E.G.**, “Lymph nodes: at the intersection of cancer treatment and progression.” Trends in Cell Biology, May 2023, PMID: 37149414, DOI: 10.1016/j.tcb.2023.04.001
** Co-corresponding authors

Linde, I.L., Prestwood, T.R., Qiu, J., Pilarowski, G.O.W., Linde, M.H., Zhang, X., Shen, L., Reticker-Flynn, N.E., Chiu. D.K.C., Sheu, L.Y., Deursen, S.V., Tolentino, L.L., Song, W.C., Englema, E.G., “Neutrophil-activating therapy for the treatment of cancer.” Cancer Cell, January 2023. PMID: 36706760, DOI: 10.1016/j.ccell.2023.01.002

Gutwillig, A., Magal, N.S., Farhat-Younis, L., Rasoulouniriana, D., Madi, A., Luxenburg, C., Cohen, J., Padmanabhan, K., Shomron, N., Shapira, G., Feinmesser, M., Zlotnik, O., Debets, R., Reticker-Flynn, N.E., Rider, P., Carmi, Y. "Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy." eLife, September 2022. PMID: 36124553, DOI: 10.7554/eLife.80315

Zhang, W., Li, I., Reticker-Flynn, N.E., Good, Z., Chang, S., Goltsev, Y., Samusik, N., Saumyaa, S., Li, Y., Zhou, X., Liang, R., Kong, C.S., Le, O.T., Gentles, A.J., Sunwoo, J.B., Nolan, G.P., Engleman, E.G., Plevritis, S.K., “Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA reveals novel spatial biology.” Nature Methods, June 2022. PMID: 35654951, DOI: 10.1038/s41592-022-01498-z

Reticker-Flynn, N.E.** and Engleman, E.G.**, “Cancer systems immunology.” eLife. July 2020. PMID: 32657757, PMCID: PMC7358011.
** Co-corresponding authors

Santana-Magal N., Farhat-Younis L., Gutwillig A., Gleiberman A., Rasoulouniriana D., Tal L., Netanely D., Shamir R., Blau R., Feinmesser M., Zlotnik O., Gutman H., Linde I.L., Reticker-Flynn N.E., Rider P., Carmi Y., “Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy.” Cancer Research. May 2020. PMID: 32127354

Rasoulouniriana, D., Santana-Magal, N., Gutwillig, A., Farhat-Younis, L., Wine, Y., Saperia, C., Tal, L., Gutman, H., Tsivian, A., Brenner, R., Bandora, E.A., Reticker-Flynn, N.E., Rider, P., Carmi, Y., “A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity.” The Journal of Clinical Investigation. August 2019. doi.org/10.1172/JCI127590

Reticker-Flynn, N.E. and Engleman, E.G., “A gut punch fights cancer and infection.” Nature (News and Views article), January 2019. PMID: 30683936.

Kenkel, J.A., Tseng, W.W., Davidson, M.G., Tolentino, L.L., Choi, O., Bhattacharya, N., Seeley, E.S., Winer, D.A., Reticker-Flynn, N.E., Engleman, E.G. “A distinct dendritic cell subset suppresses tumor immunity at secondary sites and promotes metastasis in pancreatic cancer.” Cancer Research. August 2017. PMID: 28611041, PMCID: PMC5550516.

Carmi, Y.*, Prestwood, T.R*., Spitzer, M.H., Linde, I.L., Chabon, J., Reticker-Flynn, N.E., Bhattacharya, N., Zhang, H., Zhang, X., Basto, P.A., Burt, B.M., Alonso, M.N., Engleman, E.G. “Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.” JCI Insight, November 2016. PMCID: PMC5085602
*Co-lead authors

Bhattacharya, N.*, Yuan, R.*, Prestwood, T.R., Penny, H.L., DiMaio, M.A., Reticker-Flynn, N.E., Krois, C.R., Kenkel, J.A., Pham, T.D., Carmi, Y., Tolentino, L., Choi, O., Hulett, R., Wang, J., Winer, D.A., Napoli, J.L., Engleman, E.G. “Normalizing microbiota-induced retinoic acid deficiency stimulates protective CD8+ T cell-mediated immunity in colorectal cancer.” Immunity, September 2016. PMCID: PMC5132405
*Co-lead authors

Braga Malta, D.F., Reticker-Flynn, N.E., da Silva, C.L., Cabral, J.M., Fleming, H.E., Zaret, K.S., Bhatia, S.N., Underhill, G.H. “Extracellular matrix microarrays to study inductive signaling for endoderm specification.” Acta Biomater., April 2016. PMID: 26883775

Reticker-Flynn, N.E. and Bhatia, S.N. "Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche." Cancer Discovery. February 2015. PMCID: PMC4367955.
Cover Article. This work was highlighted in Nature, Nature Reviews Cancer, and Cancer Discovery.