Publications

Featured Publications

Breuer, C.B., Xiong, Z., Wang, A., Rodriguez, G.E., Garcia, K.C., Reticker-Flynn, N.E., “Spontaneous and experimental models of lymph node metastasis.” Nature Protocols, August 2025. DOI: 10.1038/s41596-025-01200-5
News & Views

Reticker-Flynn, N.E.**, Zhang, W., Belk, J.A., Basto, P.A., Escalante, N.K., Pilarowski, G.O.W., Bejnood, A., Martins, M.M., Kenkel, J.A., Linde, I.L., Bagchi, S., Yuan, R., Chang, S., Spitzer, M.H., Carmi, Y., Cheng, J., Tolentino, L.L., Choi, O., Wu, N., Kong, C., Gentles, A.J., Sunwoo, J.B., Satpathy, A.T., Plevritis, S.K., Engleman, E.G.**, “Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.” Cell, May 2022. PMID: 35525247, DOI: 10.1016/j.cell.2022.04.019
** Co-corresponding authors
Highlighted in Nature Reviews Cancer, Nature Reviews Immunology, Cancer Discovery, Science Signaling, Trends in Cancer, NCI Cancer Currents

Spitzer, M.H.*, Carmi, Y.*, Reticker-Flynn, N.E.*, Kwek, S.S., Madhireddy, D., Martins, M.M., Gherardini, P.F., Prestwood, T.R., Chabon, J., Bendall, S.C., Fong, L., Nolan, G.P.**, Engleman, E.G.** “Systemic immunity is required for effective cancer immunotherapy.” Cell, January 2017. PMID: 28111070
* Co-lead authors; ** Co-last authors

Reticker-Flynn, N.E. and Bhatia, S.N. "Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche." Cancer Discovery. February 2015. PMCID: PMC4367955.
Highlighted in Nature Reviews Cancer, Cancer Discovery, and Nature

Reticker-Flynn, N.E., Braga Malta, D.F., Winslow, M.M., Lamar, J.M., Xu, M.J., Underhill, G.H., Hynes, R.O., Jacks, T.E., Bhatia, S.N. “A combinatorial extracellular matrix platform identifies cell-ECM interactions that correlate with metastasis.” Nature Communications. 3: October 9, 2012. PMCID: PMC3794716.

All Publications

Haist, M.*, Baertsch, M.*, Reticker-Flynn, N.E., Lu, G., Kempchen, T.N., Chu, P., Vazquez, G., Chen, H., Sunwoo, J.B., Zhang, W., Laseinde, E., Adami, B., Zimmer, S., Kaufman, J., Le, Q.T., Gentles, A., Kong, C., Plevritis, S.K., Goltsev, Y., Hickey, J., Nolan, G.P., “Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance.” Cancer Cell, January 2026. DOI: 10.1016/j.ccell.2026.01.003

Terasaki, A., Bhatnagar, K., Weiner, A.T., Tan, Y., Szeifert, V., Huang, H.L., Wiggers, L., Rodrigues, V., Rada, C.C., Shankar, V., Saito, S., Ankomah, P.O., Roth, T., Chiu, B., West, R., Li, L., Reticker-Flynn, N.E., Axelrod, J.D., Brestoff, J.R., Li, B., Engleman, E.G., Okwan-Duodu, D., “Mitochondrial transfer from immune to tumor cells enables lymph node metastasis.” Cell Metabolism. January 2026. DOI: 10.1016/j.cmet.2025.12.014

Bernard, E., Cortés-Ciriano, I., Gaiti, F., Gan, S., Jiang, S., Kovatcheva, M., Meisel, M., Reticker-Flynn, N.E., Schram, A.M., Shoshani, O., Silverbush, D., Venkataramani, V., Weeden, C.E., Zhou, X. “Reflections on Advances in Cancer Research in 2025.” Cancer Discovery (Commentary), December 2025. PMID: 41327969, DOI: 10.1158/2159-8290.CD-25-1833.

Zhang, X., McGinnis, C.M., Yu, G., Chen, S., Zheng, P., Schürch, C., Hiam-Galvez, K., Reticker-Flynn, N.E., Guo, W., Yao, W., Qiu, J., Muselman, A., Linde. I.L., Hickey, J., Yan, H., Tran, V., Qui, W., Brichart-Vernos, D., Hirai, T., Yu, B., An, X., Xiao, Y., Paidassi, H., Scharschmidt, T., Angelo, M., Sheppard, D., Chi, H., Satpathy, A.T., Way, S.S., Malissen, B., Strober, S., Engleman, E.G., “Erythropoietin receptor on cDC1s dictates immune tolerance.” Nature, December 2025. DOI: 10.1038/s41586-025-09824-z

Palma, M., Chaufan, M., Breuer, C.B., Müller, S., Sabatier, M., Fraser, C.S., Szylo, K.J., Yavari, M., Carmona, A., Kaur, M., Melo, L.M.N., Cansiz, F., Monge-Lorenzo, J., Flores, M., Mishima, E., Nakamura, T., Proneth, B., Labrado, M., Liang, Y., Cayting, N., Zheng, L., Cañeque, T., Colombeau, L., Wahida, A., Angeli, J.P.F., Tasdogan, A. Hui, S., Rodriguez, R., Conrad, M., Reticker-Flynn, N.E., Ubellacker, J.M., “Lymph node environment drives FSP1 targetability in metastasizing melanoma.” Nature, November 2025. PMID: 41193799, DOI: 10.1038/s41586-025-09709-1

Chiu, D.K.C., Zhang, X., Cheng, B.Y.L., Liu, Q., Hayashi, K., Yu, B., Lee, R., Zhang, C., An, X., Rajadas, J., Reticker-Flynn, N.E., Rankin, E., Engleman, E.G., “Unveiling tumor-derived erythropoietin as a major obstacle to effective antitumor immunity.” Science, April 2025. PMID: 40273234, DOI: 10.1126/science.adr3026

Nash, A.M., DeBonis, J., Murungi, D., Castillo, B., Kim, B., Hu, F., Chambers, C., Nguyen, A., Hernandez, A., Wang, Z., Rios, P.D., Ghani, S., Joshi, I., Isa, D., Zheng, N., Peng, W., Igoshin, O., Oberholzer, J., Hodges, H.C., Reticker-Flynn, N.E., and Veiseh, O., “IL-12-producing cytokine factories induce precursor exhausted T cells and elimination of primary and metastatic tumors.” The Journal for ImmunoTherapy of Cancer (JITC), April 2025. PMID: 40169286, PMCID: PMC11962782, DOI: 10.1136/jitc-2024-010685

Abhiraman, G., Householder, K., Rodriguez, G., Glassman, C., Saxton, R., Breuer, C.B., Wilson, S., Su, L., Yen, M., Hsu, C., Pillarisetty, V., Reticker-Flynn, N.E., Garcia, K.C., “Redirecting immune signaling with cytokine adaptors.” Nature Communications, March 2025. PMID: 40069219, PMCID: PMC11897282, DOI: 10.1038/s41467-025-57681-1

McGinnis, C.S., Miao, Z., Superville, D., Yao, W., Goga, A., Reticker-Flynn, N.E., Winkler, J.**, Satpathy, A.T.** “The temporal progression of lung immune remodeling during breast cancer metastasis.” Cancer Cell, May 2024. PMID: 38821060, DOI:https://doi.org/10.1016/j.ccell.2024.05.004
** Co-corresponding authors

Basto, P.A. and Reticker-Flynn, N.E. “Interrogating the roles of lymph node metastasis in systemic immune surveillance.” Clinical & Experimental Metastasis, February 2024. DOI: https://doi.org/10.1007/s10585-023-10261-3

Reticker-Flynn, N.E.** and Engleman, E.G.**, “Lymph nodes: at the intersection of cancer treatment and progression.” Trends in Cell Biology, May 2023, PMID: 37149414, DOI: 10.1016/j.tcb.2023.04.001
** Co-corresponding authors

Linde, I.L., Prestwood, T.R., Qiu, J., Pilarowski, G.O.W., Linde, M.H., Zhang, X., Shen, L., Reticker-Flynn, N.E., Chiu. D.K.C., Sheu, L.Y., Deursen, S.V., Tolentino, L.L., Song, W.C., Englema, E.G., “Neutrophil-activating therapy for the treatment of cancer.” Cancer Cell, January 2023. PMID: 36706760, DOI: 10.1016/j.ccell.2023.01.002

Gutwillig, A., Magal, N.S., Farhat-Younis, L., Rasoulouniriana, D., Madi, A., Luxenburg, C., Cohen, J., Padmanabhan, K., Shomron, N., Shapira, G., Feinmesser, M., Zlotnik, O., Debets, R., Reticker-Flynn, N.E., Rider, P., Carmi, Y. "Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy." eLife, September 2022. PMID: 36124553, DOI: 10.7554/eLife.80315

Zhang, W., Li, I., Reticker-Flynn, N.E., Good, Z., Chang, S., Goltsev, Y., Samusik, N., Saumyaa, S., Li, Y., Zhou, X., Liang, R., Kong, C.S., Le, O.T., Gentles, A.J., Sunwoo, J.B., Nolan, G.P., Engleman, E.G., Plevritis, S.K., “Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA reveals novel spatial biology.” Nature Methods, June 2022. PMID: 35654951, DOI: 10.1038/s41592-022-01498-z

Reticker-Flynn, N.E.** and Engleman, E.G.**, “Cancer systems immunology.” eLife. July 2020. PMID: 32657757, PMCID: PMC7358011.
** Co-corresponding authors

Santana-Magal N., Farhat-Younis L., Gutwillig A., Gleiberman A., Rasoulouniriana D., Tal L., Netanely D., Shamir R., Blau R., Feinmesser M., Zlotnik O., Gutman H., Linde I.L., Reticker-Flynn N.E., Rider P., Carmi Y., “Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy.” Cancer Research. May 2020. PMID: 32127354

Rasoulouniriana, D., Santana-Magal, N., Gutwillig, A., Farhat-Younis, L., Wine, Y., Saperia, C., Tal, L., Gutman, H., Tsivian, A., Brenner, R., Bandora, E.A., Reticker-Flynn, N.E., Rider, P., Carmi, Y., “A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity.” The Journal of Clinical Investigation. August 2019. doi.org/10.1172/JCI127590

Reticker-Flynn, N.E. and Engleman, E.G., “A gut punch fights cancer and infection.” Nature (News and Views article), January 2019. PMID: 30683936.

Kenkel, J.A., Tseng, W.W., Davidson, M.G., Tolentino, L.L., Choi, O., Bhattacharya, N., Seeley, E.S., Winer, D.A., Reticker-Flynn, N.E., Engleman, E.G. “A distinct dendritic cell subset suppresses tumor immunity at secondary sites and promotes metastasis in pancreatic cancer.” Cancer Research. August 2017. PMID: 28611041, PMCID: PMC5550516.

Carmi, Y.*, Prestwood, T.R*., Spitzer, M.H., Linde, I.L., Chabon, J., Reticker-Flynn, N.E., Bhattacharya, N., Zhang, H., Zhang, X., Basto, P.A., Burt, B.M., Alonso, M.N., Engleman, E.G. “Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.” JCI Insight, November 2016. PMCID: PMC5085602
*Co-lead authors

Bhattacharya, N.*, Yuan, R.*, Prestwood, T.R., Penny, H.L., DiMaio, M.A., Reticker-Flynn, N.E., Krois, C.R., Kenkel, J.A., Pham, T.D., Carmi, Y., Tolentino, L., Choi, O., Hulett, R., Wang, J., Winer, D.A., Napoli, J.L., Engleman, E.G. “Normalizing microbiota-induced retinoic acid deficiency stimulates protective CD8+ T cell-mediated immunity in colorectal cancer.” Immunity, September 2016. PMCID: PMC5132405
*Co-lead authors

Braga Malta, D.F., Reticker-Flynn, N.E., da Silva, C.L., Cabral, J.M., Fleming, H.E., Zaret, K.S., Bhatia, S.N., Underhill, G.H. “Extracellular matrix microarrays to study inductive signaling for endoderm specification.” Acta Biomater., April 2016. PMID: 26883775

Reticker-Flynn, N.E. and Bhatia, S.N. "Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche." Cancer Discovery. February 2015. PMCID: PMC4367955.
Cover Article. This work was highlighted in Nature, Nature Reviews Cancer, and Cancer Discovery.